[/what-is-hantavirus]
什么是汉坦病毒?
汉坦病毒是一类主要由啮齿动物传播的病毒,可在人类中引起严重疾病。
[01] 概述
一个具有两种临床面貌的病毒家族
[02] 传播
汉坦病毒如何传播至人类
大多数感染由吸入封闭空间中干燥啮齿动物排泄物的气溶胶引起。直接接触啮齿动物、咬伤或污染食物较为罕见。安第斯病毒是唯一有人传人记录的病毒株,且仅在长时间密切接触下发生。
▣ 汉坦病毒传播途径
[03] 症状
临床时间线
症状通常在暴露后 1 至 8 周出现,类似流感,随后迅速进展。早期住院能显著改善预后。
▣ 汉坦病毒肺综合征 — 临床时间线
吸入受污染气溶胶
无症状。1 至 8 周。
发热 · 肌痛 · 疲劳 · 头痛 · 胃肠症状
咳嗽 · 呼吸困难 · ARDS · 低血压
或致命结局(病死率约 25–40 %,安第斯/辛诺柏)
- 第 0 天暴露
吸入受污染气溶胶
- 第 1 – 56 天潜伏期
无症状。1 至 8 周。
- 第 1 – 5 天(前驱期)类流感期
发热 · 肌痛 · 疲劳 · 头痛 · 胃肠症状
- 第 4 – 10 天心肺期
咳嗽 · 呼吸困难 · ARDS · 低血压
- 第 10 天起利尿与恢复
或致命结局(病死率约 25–40 %,安第斯/辛诺柏)
[04] HPS / HFRS
两种综合征,两种器官
▣ HPS 与 HFRS — 临床比较
汉坦病毒肺综合征
- 地区
- 美洲
- 病毒株
- 辛诺柏 · 安第斯
- 机制
- 肺毛细血管渗漏 · 急性呼吸窘迫
肾综合征出血热
- 地区
- 欧洲 · 亚洲
- 病毒株
- 汉坦 · 首尔 · 普马拉 · 多布拉瓦
- 机制
- 急性肾损伤 · 出血 · 蛋白尿
[05] 病毒株
主要病毒株及其宿主
Andes virus
HPSAndes orthohantavirus (ANDV)
- 宿主
- Long-tailed pygmy rice rat (Oligoryzomys longicaudatus)
- 地区
- Argentina, Chile (southern South America)
- 病死率
- ~25–40%
Only hantavirus with documented person-to-person transmission. Suspected strain in MV Hondius outbreak.
CDC — Hantavirus reservoirsSin Nombre virus
HPSSin Nombre orthohantavirus (SNV)
- 宿主
- Deer mouse (Peromyscus maniculatus)
- 地区
- United States, Canada, Mexico
- 病死率
- ~36% (US)
Most common cause of hantavirus pulmonary syndrome (HPS) in North America. Identified during the 1993 Four Corners outbreak.
CDC — Hantavirus pulmonary syndromePuumala virus
HFRSPuumala orthohantavirus (PUUV)
- 宿主
- Bank vole (Myodes glareolus)
- 地区
- Northern and central Europe (Finland, Germany, France, Sweden)
- 病死率
- <0.5%
Causes a milder form of HFRS known as nephropathia epidemica. Most common hantavirus in Europe.
ECDC — Puumala virus factsheetSeoul virus
HFRSSeoul orthohantavirus (SEOV)
- 宿主
- Brown rat (Rattus norvegicus)
- 地区
- Worldwide (urban)
- 病死率
- ~1–2%
Spread globally via the brown rat. Documented outbreaks linked to pet-rat breeders.
CDC — Seoul virusHantaan virus
HFRSHantaan orthohantavirus (HTNV)
- 宿主
- Striped field mouse (Apodemus agrarius)
- 地区
- East Asia (Korea, China, Russian Far East)
- 病死率
- ~5–15%
Severe form of HFRS. Originally identified after the Korean War; gave the family its name.
WHO — Hantavirus diseaseDobrava-Belgrade virus
HFRSDobrava-Belgrade orthohantavirus (DOBV)
- 宿主
- Yellow-necked field mouse (Apodemus flavicollis)
- 地区
- Balkans, Eastern Europe
- 病死率
- ~10–12%
Causes severe HFRS in the Balkans.
ECDC — Hantavirus surveillance[06] 死亡率
死亡率一览
▣ 各病毒株病死率
[07] 预防
减少与啮齿动物接触
在欧洲和北美,目前没有获批的汉坦病毒抗病毒疗法。治疗以支持性为主。预防的重点是减少与啮齿动物的接触。
▣ 六项预防措施
封堵入口
封闭墙壁、门、屋顶和管线周围 > 6 mm 的缝隙。
防鼠存储
将食物、宠物粮和垃圾存放在密封容器中。
诱捕,不投毒
弹簧夹减少扩散。处理时戴手套。
清洁前通风
进入前先通风至少 30 分钟。
湿润,不要干扫
用 1:10 漂白液喷洒粪便。切勿干扫。
佩戴 N95/FFP2 + 手套
清洁时使用呼吸器、丁腈手套和护目镜。
[08] 历史
重要里程碑
- 1976
汉坦病毒被发现
于韩国汉滩江附近的黑线姬鼠中分离 — 病毒家族由此得名。
- 1993
四角地区疫情
在美国西南部发现辛诺柏病毒并确立 HPS。
- 2012
约塞米蒂集群
10 例 HPS 与帐篷小屋啮齿动物侵扰有关。
- 2026
MV Hondius
邮轮上首次记录的汉坦病毒疫情 — 南大西洋,4 月至 5 月。
[09] 常见问题
常见问题
Is hantavirus contagious between people?+
In almost all cases, no. Most hantaviruses spread from rodents to humans via inhaled aerosols of infected urine, droppings, or saliva. The Andes virus, found in southern South America, is the only strain with documented person-to-person transmission. (Source: CDC, WHO.)
What are the early symptoms of hantavirus?+
Early symptoms typically appear 1–8 weeks after exposure and resemble flu: fever, severe muscle aches, fatigue, headache, dizziness, chills, nausea, vomiting and abdominal pain. Within 4–10 days the disease can progress rapidly to severe respiratory distress (HPS) or kidney failure (HFRS). (Source: CDC.)
How is hantavirus diagnosed?+
Diagnosis relies on serological testing (IgM and IgG ELISA) or PCR. Because early symptoms mimic flu or COVID-19, doctors look for known exposure to rodents or recent travel to endemic regions. (Source: CDC, ECDC.)
Is there a treatment for hantavirus?+
There is no specific antiviral treatment approved for hantavirus disease. Care is supportive: oxygen therapy, fluid management, and intensive care including mechanical ventilation or dialysis where needed. Early hospitalisation improves outcomes. (Source: CDC.)
What is the mortality rate of hantavirus?+
It depends on the strain. Hantavirus pulmonary syndrome (HPS) caused by Sin Nombre virus has a case fatality rate of around 36% in the US. Andes virus is similarly severe (~25–40%). HFRS caused by Puumala virus is much milder (<0.5% mortality). (Source: CDC, ECDC.)
How can I prevent hantavirus infection?+
Reduce rodent contact: seal entry points in homes and outbuildings, store food in rodent-proof containers, and use traps. Before cleaning rodent-infested areas, ventilate for 30 minutes, wet droppings with disinfectant rather than sweeping, wear gloves and an N95/FFP2 mask, and double-bag waste. (Source: CDC cleanup guidelines.)
What happened on the MV Hondius?+
The MV Hondius, a Dutch-flagged expedition vessel, departed Ushuaia (Argentina) on 1 April 2026 with 147 people on board. Three deaths and eight cases (three lab-confirmed) of suspected hantavirus were reported between late April and early May 2026. The Andes strain has been confirmed in at least one disembarked passenger. WHO assesses the risk to the general public as low. (Source: WHO, Oceanwide Expeditions, CNN, Al Jazeera.)
Can hantavirus spread on a cruise ship?+
Hantaviruses are not airborne in the way respiratory viruses such as influenza or SARS-CoV-2 are. The Andes strain is the only one with documented person-to-person transmission, and even then, transmission requires close prolonged contact. WHO has stated the public risk from the MV Hondius outbreak is low. (Source: WHO statements, May 2026.)
Is there a hantavirus vaccine?+
No vaccine is currently licensed in Europe or North America. Inactivated-virus vaccines for Hantaan and Seoul viruses are licensed in South Korea and China. Several candidate vaccines for Andes and Sin Nombre viruses are in clinical or preclinical development. (Source: WHO.)
Where is hantavirus found in the world?+
Hantaviruses are found on every inhabited continent. Major distribution: Sin Nombre virus (Americas, North), Andes virus (Argentina/Chile), Puumala virus (Northern Europe), Hantaan and Seoul viruses (Asia and worldwide via brown rats), Dobrava-Belgrade (Balkans). (Source: WHO, CDC, ECDC.)
What is the difference between HPS and HFRS?+
Hantavirus pulmonary syndrome (HPS) primarily attacks the lungs and is caused by New World hantaviruses (Americas). Haemorrhagic fever with renal syndrome (HFRS) primarily affects the kidneys and is caused by Old World hantaviruses (Europe, Asia). HPS is generally more lethal. (Source: CDC.)
Should I cancel travel because of hantavirus?+
For most travellers, no. WHO and major travel-health authorities currently advise standard precautions, not cancellation. Avoid contact with wild rodents, do not enter rodent-infested cabins or sheds without ventilation and PPE, and follow local health advice. (Source: WHO, CDC traveller health.)
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